Study Suggests Coronavirus Vaccine May Be Linked to Temporary Changes in Menstrual Cycles

A new study has looked into the connection between menstrual health and vaccination against severe coronavirus infections. The researchers were focused on disproving reports that the coronavirus vaccine could affect menstruation cycles of women of reproductive age. These unfounded claims fostered vaccine skepticism among women as well as the general public, despite the lack of sufficient systematic research on the effects of the coronavirus vaccine on menstrual health.

For their study, the researchers looked into the correlation between the SARS-CoV-2 infection and COVID vaccination with changes in the menstrual cycle features of more than 3,000 premenopausal healthcare workers. The researchers tracked these workers, all of whom were female and resided in the United States and Canada. They sent follow-up questionnaires to every participant twice a year in the 10-year period between 2011 and 2021.

These female healthcare workers also took part in supplementary surveys regarding the coronavirus pandemic every month and every quarter from April 2020 through November 2021. These surveys allowed participants to self-report their history of positive coronavirus tests, their COVID vaccination status and the vaccine they received.

In addition, the researchers also collected information on the length and regularity of every participant’s menstrual cycle then assessed any shift in menstrual cycle features using logistic regression or multinomial logistic models.

After they had controlled for sociodemographic and behavioral characteristics, the researchers discovered that women who had received coronavirus vaccinations had a heightened risk of prolonged menstrual cycles in comparison to those who weren’t vaccinated. They also found that women with irregular, short or long pre-vaccination menstrual cycles were likely to experience a short-term increase in the duration of their menstrual cycles after they had received the coronavirus vaccine.

The researchers explained that mRNA and Adenovirus-vectored coronavirus vaccines were linked to this change in menstrual cycles.

However, they also observed that the SARS-CoV-2 infection wasn’t linked to any modification in regular features of a menstrual cycle, observing that the temporary impact of the coronavirus vaccines could have been caused by an immune reaction to the SARS-C-V-2 infection.

In their conclusion, the researchers noted that the coronavirus vaccines could be linked to short-term alternations in menstrual cycle length, especially in women whose cycles were irregular, short or long prior to vaccination. This, they noted, highlighted the importance of tracking menstrual health throughout clinical studies on vaccination.

The study’s findings were reported in the “American Journal of Obstetrics and Gynecology.”

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